Metabolites in the developing rat liver: a proton nuclear magnetic resonance spectroscopic study

Rafter, Joan E. and Bates, Timothy E. and Bell, Jimmy D. and Iles, Richard A. (1991) Metabolites in the developing rat liver: a proton nuclear magnetic resonance spectroscopic study. Biochimica et biophysica acta: general subjects, 1074 (2). pp. 263-269. ISSN 0304-4165

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Full text URL: http://dx.doi.org/10.1016/0304-4165(91)90162-A

Abstract

We have used 1H-NMR spectroscopy in vitro to investigate metabolite changes in the rat liver in the first 21 days of life. The principle findings are firstly that betaine, a metabolite of choline, was relatively low (1-2 mumol/g) on days 1-7, then rose sharply to 5-6 mumol/g by day 19, whereas approximately reciprocal changes occurred in taurine levels. Secondly the lactate levels were remarkably low (0.1-0.8 mumol/g) on days 1-7. Changes in two other choline derivatives, phosphocholine (PC) and glycerophosphorylcholine (GPC) are also reported. The results are discussed in the context of the origin of these metabolites in the neonatal period, their levels in the adult (180 day-old) rat and the significance of the measured changes in metabolite levels during liver development.

Item Type:Article
Additional Information:We have used 1H-NMR spectroscopy in vitro to investigate metabolite changes in the rat liver in the first 21 days of life. The principle findings are firstly that betaine, a metabolite of choline, was relatively low (1-2 mumol/g) on days 1-7, then rose sharply to 5-6 mumol/g by day 19, whereas approximately reciprocal changes occurred in taurine levels. Secondly the lactate levels were remarkably low (0.1-0.8 mumol/g) on days 1-7. Changes in two other choline derivatives, phosphocholine (PC) and glycerophosphorylcholine (GPC) are also reported. The results are discussed in the context of the origin of these metabolites in the neonatal period, their levels in the adult (180 day-old) rat and the significance of the measured changes in metabolite levels during liver development.
Keywords:1H, NMR Spectroscopy, Liver, Development
Subjects:C Biological Sciences > C140 Developmental/Reproductive Biology
C Biological Sciences > C141 Developmental Biology
Divisions:College of Science > School of Life Sciences
ID Code:5383
Deposited By: Timothy Bates
Deposited On:17 May 2012 16:16
Last Modified:17 May 2012 16:16

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