Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths

Murphy, Elizabeth J. and Bates, Timothy E. and Williams, Stephen R. and Watson, Tracey and Brindle, Kevin M. and Rajagopalan, Bheeshma and Radda, George K. (1992) Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. Biochimica et biophysica acta: biomembranes, 1111 (1). pp. 51-58. ISSN 0005-2736

Full text not available from this repository.

Full text URL: http://dx.doi.org/10.1016/0005-2736(92)90273-O

Abstract

31P-NMR spectra of liver in vivo, subcellular fractions and model systems were acquired in order to characterise further the hepatic phosphodiester peak seen at low magnetic field strengths previously shown to be predominantly due to phospholipid bilayers. The data obtained in this study in vitro suggested that the phospholipid membranes of the endoplasmic reticulum provide the dominant contribution to this phosphodiester peak. Support for this hypothesis was provided by experiments on rats. Phenobarbitone, which is known to induce proliferation of the endoplasmic reticulum produced a considerable increase in intensity of the phosphodiester peak in liver spectra in vivo.

Item Type:Article
Additional Information:31P-NMR spectra of liver in vivo, subcellular fractions and model systems were acquired in order to characterise further the hepatic phosphodiester peak seen at low magnetic field strengths previously shown to be predominantly due to phospholipid bilayers. The data obtained in this study in vitro suggested that the phospholipid membranes of the endoplasmic reticulum provide the dominant contribution to this phosphodiester peak. Support for this hypothesis was provided by experiments on rats. Phenobarbitone, which is known to induce proliferation of the endoplasmic reticulum produced a considerable increase in intensity of the phosphodiester peak in liver spectra in vivo.
Keywords:31P, NMR, Liver, Phosphodiester, phospholipid
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Science > School of Life Sciences
ID Code:5370
Deposited By: Timothy Bates
Deposited On:17 May 2012 16:30
Last Modified:17 May 2012 16:30

Repository Staff Only: item control page