Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver

Bates, T. E and Loesch, A. and Burnstock, G. and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochemical and biophysical research communications, 213 (3). pp. 896-900. ISSN 0006-291X

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Full text URL: http://dx.doi.org/10.1006/bbrc.1995.2213

Abstract

In this article we demonstrate the immunocytochemical localization of nitric oxide synthase in non-synaptosomal rat brain mitochondria and rat liver mitochondria, using a monoclonal antibody directed against the endothelial form of nitric oxide synthase. The possibility that nitric oxide synthase located in mitochondria is involved in the regulation of mitochondrial oxidative phosphorylation is discussed.

Item Type:Article
Additional Information:In this article we demonstrate the immunocytochemical localization of nitric oxide synthase in non-synaptosomal rat brain mitochondria and rat liver mitochondria, using a monoclonal antibody directed against the endothelial form of nitric oxide synthase. The possibility that nitric oxide synthase located in mitochondria is involved in the regulation of mitochondrial oxidative phosphorylation is discussed.
Keywords:NOS, Nitric Oxide Synthase, Synaptosomal, Mitochondria, Brain, Liver, Oxidative Phosphorylation
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
B Subjects allied to Medicine > B140 Neuroscience
A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Science > School of Life Sciences
ID Code:5345
Deposited By: Timothy Bates
Deposited On:19 May 2012 13:46
Last Modified:19 May 2012 13:46

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