Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation?

Bates, T. E. and Loesch, A. and Burnstock, G. and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochemical and biophysical research communications, 218 (1). pp. 40-44. ISSN 0006-291X

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Abstract

In this article we demonstrate the immunocytochemical localization of nitric oxide synthase in mitochondria isolated from heart, skeletal muscle, and kidney, using a monoclonal antibody directed against the endothelial form of nitric oxide synthase. The possibility that mitochondrially located nitric oxide synthase is a ubiquitous regulator of mitochondrial oxidative phosphorylation in mammalian cells is discussed.

Item Type:Article
Additional Information:In this article we demonstrate the immunocytochemical localization of nitric oxide synthase in mitochondria isolated from heart, skeletal muscle, and kidney, using a monoclonal antibody directed against the endothelial form of nitric oxide synthase. The possibility that mitochondrially located nitric oxide synthase is a ubiquitous regulator of mitochondrial oxidative phosphorylation in mammalian cells is discussed.
Keywords:Heart, Skeletal Muscle, Kidney, NOS, eNOS, Nitric Oxide Synthase, Immunocytochemistry, Immumnoelectron microscopy, Electron Microscopy, EM
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
B Subjects allied to Medicine > B140 Neuroscience
B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Science > School of Life Sciences
ID Code:5338
Deposited By: Timothy Bates
Deposited On:18 May 2012 14:45
Last Modified:18 May 2012 14:45

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