Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat

Canevari, Laura and Kuroda, Satoshi and Bates, Timothy E. and Clark, John B. and Siesjö, Bo K. (1997) Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism : official Journal of the International Society of Cerebral Blood Flow and Metabolism, 17 (11). pp. 1166-9. ISSN 0271-678X

Full text not available from this repository.

Full text URL: http://dx.doi.org/10.1097/00004647-199711000-00005

Abstract

Previous results demonstrated that after 2-hour middle cerebral artery occlusion (MCAO) in the rat, 1- to 2-hour recirculation temporarily restored the bioenergetic state and mitochondrial function, but secondary deterioration took place after 4 hours. The authors measured the activity of mitochondrial respiratory chain complexes, citrate synthase, and glutamate dehydrogenase as possible targets of secondary damage. Focal and penumbral tissues were sampled in the control condition, after 2 hours of MCAO, and after 1, 2, or 4 hours of postischemic recirculation; two groups were treated with alpha-phenyl-N-tert-butyl-nitrone (PBN). Complex IV activity transiently decreased after MCAO, but after recirculation all measured activities returned to control values.

Item Type:Article
Additional Information:Previous results demonstrated that after 2-hour middle cerebral artery occlusion (MCAO) in the rat, 1- to 2-hour recirculation temporarily restored the bioenergetic state and mitochondrial function, but secondary deterioration took place after 4 hours. The authors measured the activity of mitochondrial respiratory chain complexes, citrate synthase, and glutamate dehydrogenase as possible targets of secondary damage. Focal and penumbral tissues were sampled in the control condition, after 2 hours of MCAO, and after 1, 2, or 4 hours of postischemic recirculation; two groups were treated with alpha-phenyl-N-tert-butyl-nitrone (PBN). Complex IV activity transiently decreased after MCAO, but after recirculation all measured activities returned to control values.
Keywords:ischemia, MCAO, Mitochondrial complexes, mitochondris
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
B Subjects allied to Medicine > B140 Neuroscience
A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Science > School of Life Sciences
ID Code:5314
Deposited By: Timothy Bates
Deposited On:11 Jun 2012 17:44
Last Modified:03 May 2013 13:50

Repository Staff Only: item control page