HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state

Calabrese, Vittorio and Testa, Guiseppe and Ravagna, Agrippino and Bates, Timothy Edward and Stella, Anna Maria (2000) HSP70 induction in the brain following ethanol administration in the rat: regulation by glutathione redox state. Biochemical and Biophysical Research Communications, 269 (2). pp. 397-400. ISSN 0006-291X

Full content URL: http://dx.doi.org/10.1006/bbrc.2000.2311

Full text not available from this repository.

Item Type:Article
Item Status:Live Archive

Abstract

Changes in glutathione (GSH) and glutathione disulfide (GSSG) levels and/or redox status have been suggested to mediate the induction of heat shock proteins (HSPs) that follows exposure to oxidizing agents such as ethanol. Here we report the effects of ethanol administration to rats at intracellular levels of GSH, GSSG, HSP70, and protein carbonyls in brain and liver. Following 7 days of ethanol administration, there was a significant decrease in GSH, a significant induction of HSP70, and a significant increase in protein carbonyls in all brain regions studied and in liver. In cortex, striatum, and hippocampus there was a significant correlation between (a) the decrease in GSH, (b) the increase in GSSG, and (c) the decrease in GSH/GSSG ratio and HSP70 levels induced in response to ethanol. These data support the hypothesis that a redox mechanism may be involved in the heat-shock signal pathway responsible for HSP70 induction in the brain.

Keywords:HSP 70, glutathione, GSH, ethanol, redox
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
B Subjects allied to Medicine > B131 Cellular Pathology
B Subjects allied to Medicine > B140 Neuroscience
B Subjects allied to Medicine > B220 Toxicology
Divisions:College of Science > School of Life Sciences
ID Code:5290
Deposited On:09 Jun 2013 18:03

Repository Staff Only: item control page