Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia

Aloysius, Mark M. and Zaitoun, Abed M. and Bates, Timothy E. and Albasri, Abdulkader and Ilyas, Mohammad and Rowlands, Brian J. and Lobo, Dileep N. (2009) Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia. BMC cancer, 9 . p. 327. ISSN 1471-2407

Full content URL: http://www.biomedcentral.com/1471-2407/9/327

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Item Type:Article
Item Status:Live Archive

Abstract

Elevated serum concentrations of M2-pyruvate kinase (M2-PK) correlate with poor prognosis in patients with pancreaticobiliary and duodenal cancer, but the expression of M2-PK in formalin-fixed pancreatic tissue is unknown. We aimed to characterise the immunohistochemical expression of M2-PK in archived specimens of pancreaticobiliary and duodenal cancers, premalignant lesions, chronic pancreatitis, and normal pancreas.

Keywords:M2-pyruvate kinase, pancreatic cancer, duodenal neoplasia, epithelium neoplasia, immunohistochemistry
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
B Subjects allied to Medicine > B130 Pathology
Divisions:College of Science > School of Life Sciences
ID Code:5192
Deposited On:25 Jun 2012 21:46

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