Pokric, Maja and Allinson, Nigel M. and Jorden, A. R. and Cox, M. P. and Marshall, A. and Long, P. G. and Moon, K. and Jerram, P. and Pool, P. and Nave, C. and Derbyshire, G. E. and Helliwell, J. R. (2002) Large area high-resolution CCD-based X-ray detector for macromolecular crystallography. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment , 477 . pp. 166-171. ISSN 0168-9002

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Abstract

An X-ray detector system for macromolecular crystallography based on a large area charge-coupled device (CCD) sensor has been developed as part of a large research and development programme for advanced X-ray sensor technology, funded by industry and the Particle Physics and Astronomy Research Council (PPARC) in the UK. The prototype detector consists of two large area three-sides buttable charge-coupled devices (CCD 46-62 EEV), where the single CCD area is 55.3mm41.5 mm. Overall detector imaging area is easily extendable to 85mm110 mm. The detector consists of an optically coupled X-ray sensitive phosphor, skewed fibre-optic studs and CCDs. The crystallographic measurement requirements at synchrotron sources are met through a high spatial resolution (20481536 pixel array), high dynamic range (B105), a fast readout (B1 s), low noise (o10e) and much reduced parallax error. Additionally, the prototype detector system has been optimised by increasingits efficiency at low X-ray energies for use at conventional lab sources. The system design of the prototype detector is discussed and the proposed method for crystallographic data processing is briefly outlined.

Item Type:	Article
Additional Information:	An X-ray detector system for macromolecular crystallography based on a large area charge-coupled device (CCD) sensor has been developed as part of a large research and development programme for advanced X-ray sensor technology, funded by industry and the Particle Physics and Astronomy Research Council (PPARC) in the UK. The prototype detector consists of two large area three-sides buttable charge-coupled devices (CCD 46-62 EEV), where the single CCD area is 55.3mm41.5 mm. Overall detector imaging area is easily extendable to 85mm110 mm. The detector consists of an optically coupled X-ray sensitive phosphor, skewed fibre-optic studs and CCDs. The crystallographic measurement requirements at synchrotron sources are met through a high spatial resolution (20481536 pixel array), high dynamic range (B105), a fast readout (B1 s), low noise (o10e) and much reduced parallax error. Additionally, the prototype detector system has been optimised by increasingits efficiency at low X-ray energies for use at conventional lab sources. The system design of the prototype detector is discussed and the proposed method for crystallographic data processing is briefly outlined.
Keywords:	Data processing, Detector optimisation
Subjects:	F Physical Sciences > F131 Crystallography
Divisions:	College of Sciences > Faculty of Science > Lincoln School of Computer Science
Depositing User:	Tammie Farley
Date Deposited:	18 Feb 2012 14:05
Last Modified:	13 Mar 2013 09:04
URI:	http://eprints.lincoln.ac.uk/id/eprint/4906

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