Effects of lower limb angioplasty on endothelial-dependent and -independent microvascular reactivity

Yeung, J. M. and Klonizakis, M. and Lingam, K. and Manning, G. and Donnelly, R. (2011) Effects of lower limb angioplasty on endothelial-dependent and -independent microvascular reactivity. European Journal of Vascular and Endovascular Surgery Extra, 42 (6). p. 856. ISSN 1533-3167

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Full text URL: http://dx.doi.org/10.1016/j.ejvsextra.2011.08.001

Abstract

Background: Percutaneous Transluminal Angioplasty (PTA) of the lower limb
improves arterial flow and claudication symptoms, but the effects on cutaneous microvascular
perfusion and reactivity have not been previously reported.
Report: Cutaneous microvascular function in the feet was assessed in 12 patients with intermittent
claudication before and after PTA using Laser Doppler Fluximetry (LDF) with transcutaneous
iontophoretic administration of acetylcholine and sodium nitroprusside. Maximum
vasodilator responses to both endothelial-dependent and independent vasodilators were
increased following PTA.
Conclusions: Large vessel intervention to improve macrovascular flow has additional benefits on
the downstreamcutaneous microcirculation to improve vasodilator responsiveness. These effects
may be clinically important to reduce the risk of ischaemic ulceration and tissue breakdown.

Item Type:Article
Additional Information:Background: Percutaneous Transluminal Angioplasty (PTA) of the lower limb improves arterial flow and claudication symptoms, but the effects on cutaneous microvascular perfusion and reactivity have not been previously reported. Report: Cutaneous microvascular function in the feet was assessed in 12 patients with intermittent claudication before and after PTA using Laser Doppler Fluximetry (LDF) with transcutaneous iontophoretic administration of acetylcholine and sodium nitroprusside. Maximum vasodilator responses to both endothelial-dependent and independent vasodilators were increased following PTA. Conclusions: Large vessel intervention to improve macrovascular flow has additional benefits on the downstreamcutaneous microcirculation to improve vasodilator responsiveness. These effects may be clinically important to reduce the risk of ischaemic ulceration and tissue breakdown.
Keywords:Peripheral arterial, Angioplasty, Iontophoresis, Laser Doppler, Endothelial function, Microvascular, bmjexample
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Social Science > School of Health & Social Care
ID Code:4765
Deposited By:INVALID USER
Deposited On:01 Nov 2011 16:19
Last Modified:13 Mar 2013 09:03

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