Yeung, J. M. and Klonizakis, M. and Lingam, K. and Manning, G. and Donnelly, R. (2011) Effects of lower limb angioplasty on endothelial-dependent and -independent microvascular reactivity. European Journal of Vascular and Endovascular Surgery Extra, 42 (6). p. 856. ISSN 1533-3167

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Abstract

Background: Percutaneous Transluminal Angioplasty (PTA) of the lower limb improves arterial flow and claudication symptoms, but the effects on cutaneous microvascular perfusion and reactivity have not been previously reported. Report: Cutaneous microvascular function in the feet was assessed in 12 patients with intermittent claudication before and after PTA using Laser Doppler Fluximetry (LDF) with transcutaneous iontophoretic administration of acetylcholine and sodium nitroprusside. Maximum vasodilator responses to both endothelial-dependent and independent vasodilators were increased following PTA. Conclusions: Large vessel intervention to improve macrovascular flow has additional benefits on the downstreamcutaneous microcirculation to improve vasodilator responsiveness. These effects may be clinically important to reduce the risk of ischaemic ulceration and tissue breakdown.

Item Type:	Article
Additional Information:	Background: Percutaneous Transluminal Angioplasty (PTA) of the lower limb improves arterial flow and claudication symptoms, but the effects on cutaneous microvascular perfusion and reactivity have not been previously reported. Report: Cutaneous microvascular function in the feet was assessed in 12 patients with intermittent claudication before and after PTA using Laser Doppler Fluximetry (LDF) with transcutaneous iontophoretic administration of acetylcholine and sodium nitroprusside. Maximum vasodilator responses to both endothelial-dependent and independent vasodilators were increased following PTA. Conclusions: Large vessel intervention to improve macrovascular flow has additional benefits on the downstreamcutaneous microcirculation to improve vasodilator responsiveness. These effects may be clinically important to reduce the risk of ischaemic ulceration and tissue breakdown.
Keywords:	Peripheral arterial, Angioplasty, Iontophoresis, Laser Doppler, Endothelial function, Microvascular, bmjexample
Subjects:	A Medicine and Dentistry > A300 Clinical Medicine
Divisions:	College of Social Sciences > Faculty of Health & Social Sciences > Lincoln School of Health & Social Care
Depositing User:	Users 504951 not found.
Date Deposited:	01 Nov 2011 16:19
Last Modified:	13 Mar 2013 09:03
URI:	http://eprints.lincoln.ac.uk/id/eprint/4765

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