Atkins, S. and Sevilla, J. M. and Blazquez , M. and Pineda, T. and Gonzalez-Rodriguez, Jose (2010) Electrochemical behaviour of carbamazepine in acetonitrile and dimethylformamide using glassy carbon electrodes and microelectrodes. Electroanalysis, 22 (24). pp. 2961-2966. ISSN 1521-4109

Preview

PDF pre-refereed_version_Electroanalysis_2010.pdf - Whole Document Download (551Kb)

Abstract

The electrochemical reduction of carbamazepine in acetonitrile (ACN) and dimethylformamide (DMF) using a glassy carbon electrode and microelectrodes has been studied. The reduction process is consistent with an Electrochemical-Chemical mechanism (EC) involving a two electron transfer followed by a first order reaction, as shown by the cyclic voltammetry and differential pulse voltammetry. Half-wave potential, number of electron transfer, diffusion coefficient and rate constant of the associated chemical reaction are reported. Detection limits are in DPV: LoD=0.92 and 0.76 μg mL-1 in ACN and DMF, respectively. Precision (%RSD) and recovery (%) values when pharmaceutical compounds (200mg carbamazepine tablets) and spiked plasma samples were tested ranged from 1.09 to 9.04% and % recoveries ranged from 96 to 104.1%.

Item Type:	Article
Keywords:	carbamazepine, glassy carbon electrode, microelectrodes, voltammetry, electrochemistry, forensic science, forensic toxicology, drugs of abuse, ref03, refdoi
Subjects:	F Physical Sciences > F110 Applied Chemistry F Physical Sciences > F150 Medicinal Chemistry F Physical Sciences > F190 Chemistry not elsewhere classified F Physical Sciences > F410 Forensic Science F Physical Sciences > F100 Chemistry F Physical Sciences > F151 Pharmaceutical Chemistry F Physical Sciences > F180 Analytical Chemistry
Divisions:	College of Sciences > Faculty of Science > School of Life Sciences
Depositing User:	Jose Gonzalez-Rodriguez
Date Deposited:	16 Jun 2011 06:11
Last Modified:	08 May 2013 15:30
URI:	http://eprints.lincoln.ac.uk/id/eprint/4541

Actions (login required)

View Item