Wettability and osteoblast cell response modulation through UV laser processing of nylon 6,6

Waugh, David and Lawrence, Jonathan (2011) Wettability and osteoblast cell response modulation through UV laser processing of nylon 6,6. Applied Surface Science, 257 (21). pp. 8798-8812. ISSN 0169-4332

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Official URL: http://dx.doi.org/10.1016/j.apsusc.2011.04.044

Abstract

With an ageing population the demand for cheap, efficient implants is ever increasing. Laser surface treatment offers a unique means of varying biomimetic properties to determine generic parameters to predict cell responses. This paper details how a KrF excimer laser can be employed for both laser-induced patterning and whole area irradiative processing to modulate the wettability characteristics and osteoblast cell response following 24 hour and 4 day incubation. Through white light interferometry (WLI) it was found that the surface roughness had considerably increased by up to 1.5 µm for the laser-induced patterned samples and remained somewhat constant at around 0.1 µm for the whole area irradiative processed samples. A sessile drop device determined that the wettability characteristics differed between the surface treatments. For the patterned samples the contact angle, θ, increased by up to 25° which can be attributed to a mixed-state wetting regime. For the whole area irradiative processed samples θ decreased owed to an increase in polar component, γP. For all samples θ was a decreasing function of the surface energy. The laser whole area irradiative processed samples gave rise to a distinct correlative trend between the cell response, θ and γP. However, no strong relationship was determined for the laser-induced patterned samples due to the mixed-state wetting regime. As a result, owed to the relationships and evidence of cell differentiation one can deduce that laser whole area irradiative processing is an attractive technology for employment within regenerative medicine to meet the demands of an ageing population.

Item Type:Article
Keywords:Excimer laser, nylon 66, wettability, osteoblast cells, bioactivity, regenerative medicine
Subjects:C Biological Sciences > C131 Applied Cell Biology
H Engineering > H990 Engineering not elsewhere classified
J Technologies > J511 Engineering Materials
C Biological Sciences > C130 Cell Biology
C Biological Sciences > C110 Applied Biology
J Technologies > J410 Polymers Technology
F Physical Sciences > F361 Laser Physics
A Medicine and Dentistry > A990 Medicine and Dentistry not elsewhere classified
Divisions:College of Science > School of Engineering
ID Code:4405
Deposited By: David Waugh
Deposited On:12 Apr 2011 22:08
Last Modified:04 Dec 2013 22:51

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