Walker, A. J. and Card, T. and Bates, T. E. and Muir, K. (2011) Tricyclic antidepressants and the incidence of certain cancers: a study using the GPRD. British Journal of Cancer, 104 (1). pp. 193-197. ISSN 0007-0920

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Abstract

Background: Several studies suggest links between cancer and tricyclic antidepressant use. Methods: A case–control study using the General Practice Research Database examined whether previous tricyclic usage was associated with reduced incidence of brain (with glioma as a sub-category), breast, colorectal, lung and prostate cancers. Conditional logistic regression adjusted for age, gender, general practice, depression, smoking, body mass index, alcohol use and non-steroidal anti-inflammatory drug use. Results: A total of 31 953 cancers were identified, each matched with up to two controls. We found a statistically significant reduction in tricyclic prescriptions compared with controls in glioma (odds ratio (OR) =0.59, 95% confidence interval (CI)=0.42–0.81) and colorectal cancer patients (OR=0.84, CI=0.75–0.94). These effects were dose-dependent (P-values for trend, glioma=0.0005, colorectal=0.001) and time-dependant (P-values for trend glioma=0.0005, colorectal=0.0086). The effects were cancer-type specific, with lung, breast and prostate cancers largely unaffected by antidepressant use. Conclusion: The biologically plausible, specific and dose- and time-dependant inverse association that we have found suggests that tricyclics may have potential for prevention of both colorectal cancer and glioma.

Item Type:	Article
Keywords:	tricyclic antidepressants, glioma, colorectal cancer, GPRD, ref03, refdoi
Subjects:	C Biological Sciences > C720 Biological Chemistry
Divisions:	College of Sciences > Faculty of Science > School of Life Sciences
Depositing User:	Alison Wilson
Date Deposited:	04 Mar 2011 09:44
Last Modified:	08 May 2013 13:55
URI:	http://eprints.lincoln.ac.uk/id/eprint/4140

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