Regional variation in the mechanical properties of cortical bone from the porcine femur

Bonney, Heather and Colston, Belinda and Goodman, Adrian (2011) Regional variation in the mechanical properties of cortical bone from the porcine femur. Medical Engineering and Physics, 33 (4). pp. 513-520. ISSN 1350-4533

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Full text URL: http://dx.doi.org/10.1016/j.medengphy.2010.12.002

Abstract

Despite the widespread use of porcine bone as a substitute for human bone in the development of surgical technique and the use of fixation devices, relatively few studies have reported on the mechanical behaviour of porcine long bones. Regional variation in the mechanical properties of cortical bone from porcine femora was investigated using three-point bending and cutting tests. Results were related to measurements of bone architecture and composition and Rutherford backscattering spectrometry (RBS) was used to calculate the calcium to phosphorus ratio. There was significant, but limited, regional variation in the strength of the femur with bone from the distal, posterior quadrant (241.4  10.43 MPa) being significantly stronger than that of the lateral quadrant (162.3  17.96 MPa). Cortical bone was also anisotropic; samples cut transverse to the bone’s axis were around six times tougher than those cut parallel to the axis (p < 0.05). This corresponded with a significant negative correlation between the Young’s modulus and toughness when cut along the longitudinal axis. RBS analysis of cortical bone samples gave a Ca : P ratio of 1.37 ± 0.035, somewhat lower than that reported for cortical bone of adult human femora. These results indicate that the mechanical properties of cortical bone show significant, but limited, variation around the porcine femur and that this should be taken into consideration when sampling and choosing an appropriate animal model for orthopaedic biomechanics research.

Item Type:Article
Keywords:Porcine cortical bone, femur, toughness, Rutherford backscattering spectrometry, Young's Modulus
Subjects:F Physical Sciences > F200 Materials Science
B Subjects allied to Medicine > B830 Biomechanics, Biomaterials and Prosthetics (non-clinical)
C Biological Sciences > C900 Others in Biological Sciences
Divisions:College of Science > School of Life Sciences
ID Code:3914
Deposited By: Adrian Goodman
Deposited On:27 Jan 2011 22:32
Last Modified:04 Dec 2013 22:43

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