Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs

Engel, Odilio and Walter Muller, Hans and Klee, Rebecca and Francke, Bradley and Mills, Daniel (2019) Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs. Journal of Veterinary Internal Medicine . ISSN 0891-6640

Full content URL: https://doi.org/10.1111/jvim.15608

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Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs
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Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs
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Engel, O. et al. (2019) Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs. Journal of Veterinary Internal Medicine, 1-10..pdf - Whole Document
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Item Type:Article
Item Status:Live Archive

Abstract

Background:Noise phobia is a common behavior problem in dogs for which thereare limited treatment options.Objective:To evaluate the efficacy and safety of imepitoin in comparison to placebofor the control of anxiety and fear associated with noise phobia in dogs.Animals:Two hundred thirty-eight client-owned dogs with noise phobia were rec-ruited in veterinary clinics.Methods:This placebo-controlled, randomized, double-blinded, clinical trial used apredictable noise event as eliciting context, the traditional New Year's Eve fireworksin Germany and the Netherlands. Owners began treatment 2 days before the antici-pated noise event with administration of either imepitoin 30 mg/kg body weightQ12h or placebo for 3 consecutive days. On New Year's Eve, owners noted theirobservations of their dog's fear and anxiety behavior at 1600, 2200, 0020, and0100 hours and scored the overall treatment effect on the following day.Results:In the 16-item owner report of fear and anxiety signs, fear and anxietybehaviors were significantly reduced under imepitoin treatment compared to placebo(delta−6.1 scoring points;P< .0001). A significantly higher proportion of ownersreported a good or excellent overall treatment effect in the imepitoin group com-pared to placebo (odds ratio 4.689; 95% CI, 2.79-7.89;P< .0001).Conclusion:Imepitoin effectively controls fear and anxiety associated with noisephobia in dogs.

Keywords:anxiolytic, clinical trial, firework, imepitoin, noise aversion, noise phobia, noise sensitivity
Subjects:D Veterinary Sciences, Agriculture and related subjects > D328 Animal Welfare
D Veterinary Sciences, Agriculture and related subjects > D390 Veterinary Sciences not elsewhere classified
Divisions:College of Science > School of Life Sciences
ID Code:38082
Deposited On:28 Oct 2019 10:08

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