GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child and adult BMI

Rodriguez, Alina (2019) GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child and adult BMI. Science Advances . ISSN 2375-2548

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GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child and adult BMI
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Abstract

Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here we combine genome-wide association studies with modelling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score and co-localization analyses to determine how developmental timings, molecular pathways and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult BMI, with variants associated with adult BMI acting as early as 4-6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.

Keywords:GWAS, obesity, adiposity, life course, body mass index (BMI), development
Subjects:C Biological Sciences > C990 Biological Sciences not elsewhere classified
C Biological Sciences > C420 Human Genetics
B Subjects allied to Medicine > B990 Subjects Allied to Medicine not elsewhere classified
C Biological Sciences > C440 Molecular Genetics
Divisions:College of Social Science > School of Psychology
ID Code:36262
Deposited On:24 Jun 2019 08:00

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