The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortia: design, results and future prospects

Middeldorp, Christel and Felix, Janine and Rodriguez, Alina and Mahajan, Anubha and EArly Genetics Lifecourse Epidemiology (EAGLE) consortium, and Early Growth Genetics (EGG) consortium, and McCarthy, Mark (2019) The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortia: design, results and future prospects. European Journal of Epidemiology, 34 (3). pp. 279-300. ISSN 0393-2990

Full content URL: https://link.springer.com/article/10.1007/s10654-0...

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The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortia: design, results and future prospects
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Abstract

The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders.

Keywords:genetics, consortium, childhood traits and disorders, longitudinal
Subjects:A Medicine and Dentistry > A900 Others in Medicine and Dentistry
C Biological Sciences > C440 Molecular Genetics
C Biological Sciences > C800 Psychology
C Biological Sciences > C840 Clinical Psychology
C Biological Sciences > C420 Human Genetics
C Biological Sciences > C820 Developmental Psychology
Divisions:College of Social Science > School of Psychology
ID Code:36259
Deposited On:21 Jun 2019 07:55

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