Klonizakis, Markos and Tew, G. A. and Michaels, J. A. and Saxton, J. M. (2010) Effects of upper-limb exercise on lower-limb cutaneous microvascular function in post-surgical varicose-vein patients. European Journal of Applied Physiolology, 109 (6). pp. 1221-1224. ISSN 1439-6319

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Abstract

Regular walking exercise attenuates lower-limb cutaneous microvascular endothelial dysfunction in postsurgical varicose-vein patients. This study assessed the effects of upper-limb exercise training on lower-limb cutaneous microvascular function in this patient group. Six post-surgical (4–5 weeks) varicose-vein patients completed an 8-week arm-crank exercise training programme. Changes in cutaneous microvascular function of the lower leg were assessed using laser Doppler Xowmetry and iontophoretic administration of endothelial-dependent and -independent agonists [acetylcholine (ACh) and sodium nitroprusside (SNP), respectively]. At 8 weeks, median lower-limb cutaneous vasodilator responsives to ACh and SNP remained unchanged relative to baseline (e.g. 6 mC: 37 (interquartile range 24–63) vs. 40 (20–71) PU and 35 (23–48) vs. 38 (21–64) PU, respectively for the supine position). Upper-limb exercise appears ineffective for improving lower-limb cutaneous microvascular function in post-surgical varicose-vein patients. Therefore, limb speci- ficity appears an important factor in optimal exercise prescription for these patients.

Item Type:	Article
Additional Information:	Regular walking exercise attenuates lower-limb cutaneous microvascular endothelial dysfunction in postsurgical varicose-vein patients. This study assessed the effects of upper-limb exercise training on lower-limb cutaneous microvascular function in this patient group. Six post-surgical (4–5 weeks) varicose-vein patients completed an 8-week arm-crank exercise training programme. Changes in cutaneous microvascular function of the lower leg were assessed using laser Doppler Xowmetry and iontophoretic administration of endothelial-dependent and -independent agonists [acetylcholine (ACh) and sodium nitroprusside (SNP), respectively]. At 8 weeks, median lower-limb cutaneous vasodilator responsives to ACh and SNP remained unchanged relative to baseline (e.g. 6 mC: 37 (interquartile range 24–63) vs. 40 (20–71) PU and 35 (23–48) vs. 38 (21–64) PU, respectively for the supine position). Upper-limb exercise appears ineffective for improving lower-limb cutaneous microvascular function in post-surgical varicose-vein patients. Therefore, limb speci- ficity appears an important factor in optimal exercise prescription for these patients.
Keywords:	Skin blood flow, Upper-limb exercise, Venous disease, Laser Doppler flowmetry
Subjects:	A Medicine and Dentistry > A300 Clinical Medicine
Divisions:	College of Social Sciences > Faculty of Health & Social Sciences > Lincoln School of Health & Social Care
Depositing User:	Users 504951 not found.
Date Deposited:	28 Oct 2010 14:22
Last Modified:	13 Mar 2013 08:49
URI:	http://eprints.lincoln.ac.uk/id/eprint/3540

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