Arginine vasopressin in cerebrospinal fluid is a marker of sociality in nonhuman primates

Parker, K.J. and Garner, J.P. and Oztan, O. and Tarara, E.R. and Li, J. and Sclafani, Valentina and Del Rosso, L.A. and Chun, K. and Berquist, S.W. and Chez, M.G. and Partap, S. and Hardan, A.Y. and Sherr, E.H. and Capitanio, J.P. (2018) Arginine vasopressin in cerebrospinal fluid is a marker of sociality in nonhuman primates. Science Translational Medicine, 10 (439). ISSN 1946-6234

Full content URL: https://doi.org/10.1126/scitranslmed.aam9100

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Arginine vasopressin in cerebrospinal fluid is a marker of sociality in nonhuman primates
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Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by core social impairments. ASD remains poorly understood because of the difficulty in studying disease biology directly in patients and the reliance on mouse models that lack clinically relevant, complex social cognition abilities. We use ethological observations in rhesus macaques to identify male monkeys with naturally occurring low sociality. These monkeys showed differences in specific neuropeptide and kinase signaling pathways compared to socially competent male monkeys. Using a discovery and replication design, we identified arginine vasopressin (AVP) in cerebrospinal fluid (CSF) as a key marker of group differences in monkey sociality; we replicated these findings in an independent monkey cohort. We also confirmed in an additional monkey cohort that AVP concentration in CSF is a stable traitlike measure. Next, we showed in a small pediatric cohort that CSF AVP concentrations were lower in male children with ASD compared to age-matched male children without ASD (but with other medical conditions). We demonstrated that CSF AVP concentration was sufficient to accurately distinguish ASD cases from medical controls. These data suggest that AVP and its signaling pathway warrant consideration in future research studies investigating new targets for diagnostics and drug development in ASD. © 2018 The Authors.

Additional Information:cited By 4
Keywords:argipressin, biological marker, phosphotransferase, adult, animal behavior, animal experiment, Article, autism, child, clinical article, cohort analysis, controlled study, diagnostic accuracy, drug development, human, male, nonhuman, preschool child, priority journal, protein cerebrospinal fluid level, rhesus monkey, school child, signal transduction, social behavior, young adult
Subjects:C Biological Sciences > C120 Behavioural Biology
C Biological Sciences > C800 Psychology
C Biological Sciences > C820 Developmental Psychology
B Subjects allied to Medicine > B990 Subjects Allied to Medicine not elsewhere classified
Divisions:College of Social Science > School of Psychology
ID Code:34824
Deposited On:12 Apr 2019 08:58

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