CALR and CD47: An insight into their roles in the disease progression of MDS and MPN

Boasman, Kristian and Simmonds, Matthew and Rinaldi, Ciro (2018) CALR and CD47: An insight into their roles in the disease progression of MDS and MPN. Journal of Blood Disorders & Transfusion . ISSN 2155-9864

Full content URL: https://www.omicsonline.org/open-access/calr-and-c...

Documents
VERSION 8 CALR CD47 After Reviewers Comments ACCEPTED Black Text.docx

Request a copy
CALR and CD47: An Insight into Their Roles in the Disease Progression of MDS and MPN
[img]
[Download]
[img] Microsoft Word
VERSION 8 CALR CD47 After Reviewers Comments ACCEPTED Black Text.docx
Restricted to Repository staff only

112kB
[img] PDF
calr-and-cd47-an-insight-into-their-roles-in-the-disease-progression-of-mds-and-mpn-2155-9864-1000413.pdf - Whole Document

350kB
Item Type:Article
Item Status:Live Archive

Abstract

Myelodysplastic syndrome and myeloproliferative neoplasms are clonal myeloid disorders arising from haematopoietic stem cells that have the tendency to progress into acute myeloid leukaemia. Multiple prognostic scoring systems have been proposed and utilised in clinical practice to predict disease evolution, however none of them can predict treatment response. In solid tumours, the relationship between the pro-phagocytic calreticulin and the anti-phagocytic CD47 is repeatedly investigated. Overexpression of calreticulin has been documented to produce a pro-phagocytic signal in solid tumour and it is often counteracted by a concomitant expression of the anti-phagocytic CD47 as they act in response to one another, reflecting an apoptosis vs survival mechanism in response to chemotherapy. The role of both calreticulin and CD47 are currently poorly understood in myeloid malignancies including myelodysplastic syndrome and myeloproliferative neoplasms. The aim of this review is to elaborate on the current understanding round the roles and implications of calreticulin and CD47 signalling with in solid and haematological cancers, discuss potential roles for calreticulin and CD47 expression in transformation of myeloid cells in patients with MDS or MPN into AML and how these advances are starting to be used to design new therapeutic strategies to determine disease progression and treatment response in both solid cancer and myeloid malignancies.

Keywords:Haematological cancers, JAK/STAT, CD47, CALR, acute myeloid leukaemia, myeloproliferative neoplasms, myelodysplastic syndrome, solid cancers
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
Divisions:College of Science > School of Life Sciences
Related URLs:
ID Code:34319
Deposited On:14 Jan 2019 15:39

Repository Staff Only: item control page