PRaVDA: The First Solid-State System for Proton Computed Tomography

Esposito, Michela and Waltham, Chris and Allinson, Nigel and Taylor, Jon and Manger, Sam and Phoenix, Ben and Price, Tony and Poludniowski, Gavin and Green, Stuart and Evans, Phil and Allport, Phil and Manolopulos, Spyros and Nieto-Camero, Jaime and Symons, Julyan (2018) PRaVDA: The First Solid-State System for Proton Computed Tomography. Journal of Physica Medica, 55 . pp. 149-154. ISSN 1120-1797

Full content URL: https://doi.org/10.1016/j.ejmp.2018.10.020

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PRaVDA: The First Solid-State System for Proton Computed Tomography
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Abstract

Proton CT is widely recognised as a beneficial alternative to con- ventional X-ray CT for treatment planning in proton beam radiotherapy. A novel proton CT imaging system, based entirely on solid-state detec- tor technology, is presented. Compared to conventional scintillator-based calorimeters, positional sensitive detectors allow for multiple protons to be tracked per read out cycle, leading to a potential reduction in proton CT scan time. Design and characterisation of its components are discussed. An early proton CT image obtained with a fully solid-state imaging sys- tem is shown and accuracy (as defined in Section IV) in Relative Stopping Power to water (RSP) quantified.
A solid-state imaging system for proton CT, based on silicon strip detectors, has been developed by the PRaVDA collaboration. The sys- tem comprises a tracking system that infers individual proton trajecto- ries through an imaging phantom, and a Range Telescope (RT) which records the corresponding residual energy (range) for each proton. A back-projection-then-filtering algorithm is used for CT reconstruction of an experimentally acquired proton CT scan.
An initial experimental result for proton CT imaging with a fully solid-state system is shown for an imaging phantom, namely a 75 mm diameter PMMA sphere containing tissue substitute inserts,imaged with a passively-scattered 125 MeV beam. Accuracy in RSP is measured to be ≤1.6% for all the inserts shown.
A fully solid-state imaging system for proton CT has been shown capable of imaging a phantom with protons and successfully improving RSP accuracy. These promising results, together with system the capabil- ity to cope with high proton fluences (2×108 protons/s), suggests that this research platform could improve current standards in treatment planning for proton beam radiotherapy.

Keywords:proton CT, proton therapy, medical physics
Subjects:F Physical Sciences > F350 Medical Physics
Divisions:College of Science
ID Code:33999
Deposited On:07 Nov 2018 12:53

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