The effect of cathodal transcranial direct current stimulation during rapid eye-movement sleep on neutral and emotional memory

Johnson, Jennifer and Durrant, Simon (2018) The effect of cathodal transcranial direct current stimulation during rapid eye-movement sleep on neutral and emotional memory. Royal Society Open Science, 5 (7). ISSN 2054-5703

Full content URL: https://doi.org/10.1098/rsos.172353

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The effect of cathodal transcranial direct current stimulation during rapid eye-movement sleep on neutral and emotional memory

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Item Type:Article
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Abstract

Sleep-dependent memory consolidation has been extensively studied. Neutral declarative memories and serial reaction
time task (SRTT) performance can benefit from slow-wave activity, characterized by less than 1 Hz frequency cortical
slow oscillations (SO). Emotional memories can benefit from theta activity, characterized by 4–8 Hz frequency cortical
oscillations. Applying transcranial direct current stimulation (tDCS) during sleep entrains specific frequencies to alter sleep architecture. When applying cathodal tDCS (CtDCS), neural inhibition or excitation may depend on the waveform at the applied frequency. A double dissociation was predicted, with CtDCS at SO frequency improving neutral declarative memory and SRTT performance, and theta frequency CtDCS inhibiting negative emotional memory. Participants completed three CtDCS conditions (Theta: 5Hz, SO: 0.75 Hz and control: Sham) and completed an SRTT and word recognition task pre- and post-sleep, comprising emotional and neutral words to assess memory. In line with predictions, CtDCS improved neutral declarative memory when applied at SO frequency. When applied at theta frequency, no negative emotional word memory impairment was found but a positive association was found between post-stimulation theta power and emotional word recognition. SRTT performance was also not altered by either CtDCS frequency. Future studies should investigate overnight theta CtDCS and examine the effects of CtDCS during and after stimulation.

Keywords:sleep, tDCS, REM, memory, emotion
Subjects:B Subjects allied to Medicine > B140 Neuroscience
C Biological Sciences > C830 Experimental Psychology
C Biological Sciences > C850 Cognitive Psychology
C Biological Sciences > C800 Psychology
Divisions:College of Social Science > School of Psychology
ID Code:32663
Deposited On:17 Jul 2018 10:18

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