Porous metal organic framework nanoparticles to address the challenges related to busulfan encapsulation

Chalati, Tamim and Horcajada, P and Couvreur, P and Serre, C and Ben Yahia, M and Maurin, G and Gref, R (2011) Porous metal organic framework nanoparticles to address the challenges related to busulfan encapsulation. Nanomedicine, 6 (10). pp. 1683-1695. ISSN 1743-5889

Full content URL: http://doi.org/10.2217/nnm.11.69

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Porous metal organic framework nanoparticles to address the challenges related to busulfan encapsulation
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Abstract

Busulfan is an alkylating agent widely used in chemotherapy, but with severe side effects. Many attempts
have been made to entrap busulfan in nanocarriers to avoid liver accumulation and to protect it against
rapid degradation in aqueous media. However, poor loadings
(
=5 wt%) and fast release were generally
obtained due to the low affinity of busulfan towards the nanocarriers. Moreover, drug crystallization
often occurred during nanoparticle preparation. To circumvent these drawbacks, metal organic framework (MOF) nanoparticles, based on crystalline porous iron (III) carboxylates, have shown an unprecedented loading (up to 25 wt%) of busulfan. This was attributed to the high porosity of nanoMOFs as well as to their hydrophilic–hydrophobic internal microenvironment well adapted to the amphiphilic character of busulfan. NanoMOFs formulations have kept busulfan in molecular form, preventing its crystallization and degradation. Indeed, busulfan was released intact, as proved by the maintenance of its pharmacological activity.

Additional Information:The final published version of this article is available online at https://www.futuremedicine.com/doi/10.2217/nnm.11.69
Keywords:busulfan cytotoxicity drug crystallization drug loading drug release iron (III) carboxylate nanoparticle NMR porous MOF
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
Divisions:College of Science > School of Pharmacy
ID Code:32573
Deposited On:13 Aug 2018 09:56

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