Structural motifs in salts of sulfathiazole: implications for design of salt forms in pharmaceuticals APIs†

Munshi, Tasnim and Scowen, Ian and Seaton, Colin C. and Thomas, Rayan R. and Essifaow, Eman A. A. and Nauha, Elisa Structural motifs in salts of sulfathiazole: implications for design of salt forms in pharmaceuticals APIs†. CrystEngComm . ISSN 1466-803

Full content URL: http://pubs.rsc.org/en/content/articlelanding/2018...

Documents
Structural motifs in salts of sulfathiazole: implications for design of salt forms in pharmaceuticals APIs†

Request a copy
[img] PDF
C8CE00606G.pdf - Whole Document
Restricted to Repository staff only until 2019.

2MB
Item Type:Article
Item Status:Live Archive

Abstract

The creation of salts is a frequently used approach for the modification of physicochemical properties of
an active pharmaceutical ingredient. Despite the frequency of application, there has been little research
into the structural–property relationships of the final material and the nature of the counterion present. This
work reports on five new salts of sulfathiazole and compares the energetics of the intermolecular interactions
with variation in the crystal packing motifs.

Keywords:salts of sulfathiazole, crystal packing motifs
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
ID Code:32254
Deposited On:04 Jun 2018 12:21

Repository Staff Only: item control page