1,4‐Dithiane‐2,5‐diol: An Attractive Platform for the Synthesis of Sulfur Containing Functionalized Heterocycles

Francesco, Zamberlan and Anna, Fantinati and Claudio, Trapella (2018) 1,4‐Dithiane‐2,5‐diol: An Attractive Platform for the Synthesis of Sulfur Containing Functionalized Heterocycles. European Journal of Organic Chemistry, 2018 (25). pp. 3248-3264. ISSN 1434-193X

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1,4‐Dithiane‐2,5‐diol: An Attractive Platform for the Synthesis of Sulfur Containing Functionalized Heterocycles
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Abstract

This microreview highlights the utility of 1,4? dithiane?2,5?diol 1 as a source for the in situ generation of 2?mercaptoacetaldehyde 2, a versatile two?carbon synthon featuring both electrophilic and nucleophilic reaction centers widely utilized as an attractive platform for the preparation of sulfur?containing molecules. We discussed the involved chemistry, mainly focusing on its applications to the construction of sulfur?containing heterocyclic compounds including the thiophene and 1,3?thiazole families and other different sulfur?nitrogen and sulfur?oxygen heterocycles which continue to be a pillar of organic synthesis as a result of their broad application in organic and medicinal chemistry.

Keywords:1,4-Dithiane-2,5-diol, Heterocycles, Thiophene, Michael/Aldol reactions
Subjects:F Physical Sciences > F150 Medicinal Chemistry
F Physical Sciences > F160 Organic Chemistry
F Physical Sciences > F151 Pharmaceutical Chemistry
Divisions:College of Science > School of Chemistry
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ID Code:32113
Deposited On:27 Jun 2018 22:02

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