Genetic rescue of absence seizures

McCafferty, Cian and Connelly, William M. and Celli, Roberta and Ngomba, Richard T. and Nicoletti, Ferdinando and Crunelli, Vincenzo (2018) Genetic rescue of absence seizures. CNS Neuroscience & Therapeutics . ISSN 1755-5930

Full content URL: http://doi.org/10.1111/cns.12858

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Abstract

Crossbreeding GABAAR δ subunit knockout mice with stargazer mice removes the absence seizure phenotype
Thalamic tonic GABAA current is similarly abolished
Rescue also occurs with acute siRNA knockdown of δ subunit
Ataxic phenotype of stargazer is partially ameliorated

Keywords:Seizures, Genetics
Subjects:C Biological Sciences > C431 Medical Genetics
Divisions:College of Science > School of Chemistry
ID Code:31998
Deposited On:08 May 2018 09:22

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