Spared and impaired sleep-dependent memory consolidation in schizophrenia

Baran, Bengi and Correll, David and Vuper, Tessa C and Morgan, Alexandra and Durrant, Simon J and Manoach, Dara S and Stickgold, Robert (2018) Spared and impaired sleep-dependent memory consolidation in schizophrenia. Schizophrenia Research . ISSN 0920-9964

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Item Type:Article
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Abstract

Objective: Cognitive deficits in schizophrenia are the strongest predictor of disability and effective treatment is
lacking. This reflects our limited mechanistic understanding and consequent lack of treatment targets. In
schizophrenia, impaired sleep-dependent memory consolidation correlates with reduced sleep spindle activity,
suggesting sleep spindles as a potentially treatable mechanism. In the present study we investigated whether
sleep-dependent memory consolidation deficits in schizophrenia are selective.
Methods: Schizophrenia patients and healthy individuals performed three tasks that have been shown to
undergo sleep-dependent consolidation: the Word Pair Task (verbal declarative memory), the Visual
Discrimination Task (visuoperceptual procedural memory), and the Tone Task (statistical learning). Memory
consolidation was tested 24h later, after a night of sleep.
Results: Compared with controls, schizophrenia patients showed reduced overnight consolidation of word pair
learning. In contrast, both groups showed similar significant overnight consolidation of visuoperceptual
procedural memory. Neither group showed overnight consolidation of statistical learning.
Conclusion: The present findings extend the known deficits in sleep-dependent memory consolidation in
schizophrenia to verbal declarative memory, a core, disabling cognitive deficit. In contrast, visuoperceptual
procedural memory was spared. These findings support the hypothesis that sleep-dependent memory
consolidation deficits in schizophrenia are selective, possibly limited to tasks that rely on spindles. These
findings reinforce the importance of deficient sleep-dependent memory consolidation among the cognitive
deficits of schizophrenia and suggest sleep physiology as a potentially treatable mechanism.

Keywords:schizophrenia, sleep, memory consolidation, declarative memory, procedural memory, statistical learning
Subjects:C Biological Sciences > C850 Cognitive Psychology
B Subjects allied to Medicine > B140 Neuroscience
C Biological Sciences > C840 Clinical Psychology
Divisions:College of Social Science > School of Psychology
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ID Code:31740
Deposited On:19 Jun 2018 20:37

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