Supramolecular receptors for the recognition and discrimination of epigenetically modified lysines

Gruber, Tobias (2018) Supramolecular receptors for the recognition and discrimination of epigenetically modified lysines. In: Chemiedozententagung 2018, 5 -7 March 2018, Jena, Germany.

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Item Type:Conference or Workshop contribution (Lecture)
Item Status:Live Archive

Abstract

One focus of this presentation is on a water-soluble macrocycle and its ability to recognize differently methylated lysines. The results show that the host molecule discriminates lower methylated lysines, while higher methylated ones bind rather selectively. Binding studies were carried out with respectively methylated lysines using NMR spectroscopy and our findings have been analyzed by energy-minimization calculations.
A second focus is on macrocycles with intrinsic fluorescence. We suggested the name ‘fluorescophane’ for such macrocyclic compounds. By inserting a condensed aromatic system, the resulting receptor is envisaged to enable better C−H···π and cation···π interactions with a respective alkyl ammonium ion and at the same time allow an efficient quantification of host/guest interactions.

Keywords:macrocycle, calixarene, fluorescophane
Subjects:F Physical Sciences > F151 Pharmaceutical Chemistry
F Physical Sciences > F160 Organic Chemistry
F Physical Sciences > F150 Medicinal Chemistry
Divisions:College of Science > School of Pharmacy
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ID Code:31282
Deposited On:09 Mar 2018 12:48

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