Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging

Zamberlan, Francesco and Turyanska, Lyudmila and Patane, Amalia and Liu, Zhimin and Williams, Huw and Fay, Michael and Clarke, Philip and Imamura, Yukio and Jin, Takashi and Bradshaw, Tracey and Thomas, Neil and Grabowska, Anna (2018) Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging. Journal of Materials Chemistry B, 6 (4). pp. 550-555. ISSN 2050-750x

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The short shelf-life of water-soluble quantum dots (QDs) due to colloidal instability represents a major drawback to their exploitation. This work examines the colloidal stability of PbS nanoparticles capped with dihydrolipoic acid–polyethylene glycol (DHLA–PEG) ligands terminated with functional groups such as –NH2, –COOH, OMe and –N3.
and their application for in vivo imaging. We prove a mechanism of colloidal instability and develop a strategy to produce for the first time stable PEG-capped PbS quantum dots with high quantum yield and optical emission in the first and the second near-infrared (NIR) windows of low absorption of biological tissues. The NIR imaging of in vivo
biodistribution is demonstrated at wavelengths 41000 nm, with benefits of reduced tissue absorption and light scattering. The stability, biocompatibility and potential for further QD functionalization open up realistic prospects for non-invasive bioimaging applications.

Keywords:quantum dots, bioimaging, nearinfrared
Subjects:F Physical Sciences > F100 Chemistry
F Physical Sciences > F200 Materials Science
Divisions:College of Science > School of Chemistry
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ID Code:30389
Deposited On:22 Jan 2018 16:29

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