Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer

Zamberlan, Francesco and Lesbats, Clémentine and Rogers, Nicola J. and Krupa, James L. and Pavlovskaya, Galina E. and Thomas, Neil R. and Faas, Henryk M. and Meersmann, Thomas (2015) Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer. ChemPhysChem, 16 (11). pp. 2294-2298. ISSN 1439-4235

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Item Type:Article
Item Status:Live Archive

Abstract

An approach for hyperpolarized (129) Xe molecular sensors is explored using paramagnetic relaxation agents that can be deactivated upon chemical or enzymatic reaction with an analyte. Cryptophane encapsulated (129) Xe within the vicinity of the paramagnetic center experiences fast relaxation that, through chemical exchange of xenon atoms between cage and solvent pool, causes accelerated hyperpolarized (129) Xe signal decay in the dissolved phase. In this proof-of-concept work, the relaxivity of Gadolinium(III) -DOTA on (129) Xe in the solvent was increased eightfold through tethering of the paramagnetic molecule to a cryptophane cage. This potent relaxation agent can be 'turned off' specifically for (129) Xe through chemical reactions that spatially separate the Gd(III) centre from the attached cryptophane cage. Unlike (129) Xe chemical shift based sensors, the new concept does not require high spectral resolution and may lead to a new generation of responsive contrast agents for molecular MRI.

Keywords:Hyperpolarisation, Molecular Imaging, Cryptophane, Xenon
Subjects:F Physical Sciences > F170 Physical Chemistry
F Physical Sciences > F110 Applied Chemistry
F Physical Sciences > F160 Organic Chemistry
F Physical Sciences > F350 Medical Physics
F Physical Sciences > F320 Chemical Physics
Divisions:College of Science > School of Chemistry
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ID Code:30366
Deposited On:06 Mar 2018 11:01

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