Brain hypometabolism of glucose in anorexia nervosa: A PET scan study

Delvenne, Véronique and Lotstra, Françoise and Goldman, Serge and Biver, Françoise and De Maertelaer, Viviane and Appelboom-Fondu, Jocelyne and Schoutens, André and Bidaut, Luc and Luxen, André and Mendelwicz, Julien (1995) Brain hypometabolism of glucose in anorexia nervosa: A PET scan study. Biological Psychiatry, 37 (3). pp. 161-169. ISSN 0006-3223

Full content URL: http://doi.org/10.1016/0006-3223(94)00189-a

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Item Type:Article
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Abstract

Cerebral glucose metabolism was studied in 20 underweight anorectic girls and in 10 age- and sex-matched healthy volunteers using positron emission tomography with (18-F)-fluorodeoxy-glucose. Both groups were scanned during rest, with eye closed and with low ambient noise. Compared to controls, the underweight anorectic group showed a global hypometabolism (p = .002) and an absolute (p < .001) as well as relative (p < .01) hypometabolism of glucose in cortical regions, with the most significant differences found in the frontal and the parietal cortices. Within the underweight anorectic and the control groups, no correlations were found between absolute or relative rCMRGlu and BMI, anxiety scores, or Hamilton scores of depression. Different factors might explain this reduction of glucose metabolism in anorexia nervosa. It might be the consequence of neurophysiological or morphological aspects of anorexia nervosa and/or the result of some associated symptoms such as anxiety or depressed feelings. Supported by cognitive studies, we can also hypothesize a primary corticocerebral dysfunctioning in anorexia nervosa.

Additional Information:The final published version of this article can be accessed online at https://www.sciencedirect.com/science/article/pii/000632239400189A?via%3Dihub
Keywords:anorexia nervosa, PET scan, FDG;, cerebral metabolism
Subjects:F Physical Sciences > F350 Medical Physics
Divisions:College of Science > School of Computer Science
ID Code:29494
Deposited On:13 Aug 2018 13:58

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