The use of imepitoin (Pexion™) on fear and anxiety related problems in dogs – a case series

McPeake, Kevin J. and Mills, Daniel S. (2017) The use of imepitoin (Pexion™) on fear and anxiety related problems in dogs – a case series. BMC Veterinary Research, 13 (1). p. 173. ISSN 1746-6148

Full content URL: http://doi.org/10.1186/s12917-017-1098-0

Documents
29343.pdf
[img]
[Download]
[img]
Preview
PDF
29343.pdf - Whole Document
Available under License Creative Commons Attribution 4.0 International.

404kB
Item Type:Article
Item Status:Live Archive

Abstract

Fear and anxiety based problems are common in dogs. Alongside behaviour modification programmes, a range of psychopharmacological agents may be recommended to treat such problems, but few are licensed for use in dogs and the onset of action of some can be delayed. The low affinity partial benzodiazepine receptor agonist imepitoin (Pexion™, Boehringer Ingelheim) is licensed for treating canine epilepsy, has a fast onset of action in dogs and has demonstrated anxiolytic properties in rodent models. This case series reports on the use of imepitoin in a group of dogs identified as having fear/anxiety based problems. Twenty dogs were enrolled into the study, attended a behaviour consultation and underwent routine laboratory evaluation. Nineteen dogs proceeded to be treated with imepitoin orally twice daily (starting dose approximately 10 mg/kg, with alterations as required to a maximum 30 mg/kg) alongside a patient-specific behaviour modification plan for a period of 11–19 weeks. Progress was monitored via owner report through daily diary entries and telephone follow-up every two weeks. A Positive and Negative Activation Scale (PANAS) of temperament was also completed by owners during baseline and at the end of the study.

Keywords:Animal behaviour, Anxiety, Dog, Drug, Fear, GABA, Imepitoin
Subjects:D Veterinary Sciences, Agriculture and related subjects > D210 Clinical Veterinary Medicine
Divisions:College of Science > School of Life Sciences
Related URLs:
ID Code:29343
Deposited On:13 Nov 2017 10:41

Repository Staff Only: item control page