Effects of plant derived flavenoids and polyphenolic acids on the activity of mutagens from cooked food

Alldrick, A. J. and Flynn, John and Rowland , I. R. (1986) Effects of plant derived flavenoids and polyphenolic acids on the activity of mutagens from cooked food. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 163 (3). pp. 225-232. ISSN 0027-5107

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Full text URL: http://dx.doi.org/10.1016/0027-5107(86)90020-5

Abstract

The ability of 3 plant flavonoids (morin, myricetin and quercetin) and 4 polyphenolic acids (caffeic acid, chlorogenic acid, ellagic acid and ferulic acid) to inhibit the genotoxic effects of a number of cooked-food mutagens (IQ, MeIQ, MeIQx, Trp-P-1 and Trp-P-2), was investigated in a bacterial mutation assay using Salmonella typhimurium TA98 as indicator and hepatic S9 mixes from either SWR mice or Syrian hamster as metabolic activating systems. Although the polyphenolic acids failed to have an effect, the flavonoids generally inhibited IQ, MeIQ, MeIQx and Trp-P-1 induced mutagenesis in a dose-dependent manner, irrespective of the source of S9. This was not the case with Trp-P-2 where the flavonoids were only observed to inhibit when SWR mouse S9 but not Syrian hamster S9 was used. Of the 3 compounds, myricetin and quercetin were superior to morin in their inhibitory capacity.

Item Type:Article
Additional Information:The ability of 3 plant flavonoids (morin, myricetin and quercetin) and 4 polyphenolic acids (caffeic acid, chlorogenic acid, ellagic acid and ferulic acid) to inhibit the genotoxic effects of a number of cooked-food mutagens (IQ, MeIQ, MeIQx, Trp-P-1 and Trp-P-2), was investigated in a bacterial mutation assay using Salmonella typhimurium TA98 as indicator and hepatic S9 mixes from either SWR mice or Syrian hamster as metabolic activating systems. Although the polyphenolic acids failed to have an effect, the flavonoids generally inhibited IQ, MeIQ, MeIQx and Trp-P-1 induced mutagenesis in a dose-dependent manner, irrespective of the source of S9. This was not the case with Trp-P-2 where the flavonoids were only observed to inhibit when SWR mouse S9 but not Syrian hamster S9 was used. Of the 3 compounds, myricetin and quercetin were superior to morin in their inhibitory capacity.
Keywords:cooked-food mutagens, plant derived flavenoids acids, plant drived polyphenolic acids
Subjects:C Biological Sciences > C560 Biotechnology
Divisions:College of Social Science > School of Health & Social Care
ID Code:2893
Deposited By: Rosaline Smith
Deposited On:14 Jul 2010 13:40
Last Modified:24 Sep 2012 14:34

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