Teixobactin and its analogues: a new hope in antibiotic discovery

Fiers, William D. and Craighead, Mark and Singh, Ishwar (2017) Teixobactin and its analogues: a new hope in antibiotic discovery. ACS Infectious Diseases . ISSN 2373-8227

Full content URL: http://dx.doi.org/10.1021/acsinfecdis.7b00108

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Abstract

Increasing bacterial resistance against current antibiotics and lack of new molecules to combat bacterial resistance
are key challenges to global health. There is, therefore, a continuing need to develop new antibiotics. Teixobactin, a cyclic
undecapeptide, displays excellent antibacterial activities against a range of pathogenic bacteria, such as methicillin-resistant
Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis. Interestingly, it operates by multiple modes of actions and is
bactericidal toward S. aureus without detectable resistance. This unique combination of wide Gram-positive activity coupled with
its inability to elicit resistance make teixobactin a very attractive molecule for antimicrobial therapeutic development. This
Viewpoint discusses teixobactin, its analogues, and the challenges and opportunities associated with their future development.

Keywords:Teixobactins, antibiotics, Lipid II
Subjects:F Physical Sciences > F160 Organic Chemistry
F Physical Sciences > F163 Bio-organic Chemistry
C Biological Sciences > C500 Microbiology
Divisions:College of Science > School of Pharmacy
ID Code:28442
Deposited On:24 Aug 2017 14:51

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