High human cytomegalovirus loads and diverse linked variable genotypes in both HIV-1 infected and exposed, but uninfected, children in Africa

Bates, Matthew and Monze, M. and Bima, H. and Kapambwe, M. and Kasolo, F. C. and Gompels, U. A. and Grp, CIGNIS Study (2008) High human cytomegalovirus loads and diverse linked variable genotypes in both HIV-1 infected and exposed, but uninfected, children in Africa. VIROLOGY, 382 (1). pp. 28-36. ISSN 0042-6822

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Abstract

Human cytomegalovirus, HCMV, was analysed using real-time quantitative PCR in symptomatic or asymptomatic pediatric cohorts from HIV-1 infected, exposed (HIV-1+ mothers), or uninfected groups in Zambia, an HIV-1/AIDS endemic region of Africa. HCMV infections were identified in 94% samples from HIV-1+ respiratory pediatric mortalities, 50% with high DNA loads of 10(3)-10(8) copies/10(6) cells. In comparison, HCMV viremia with high DNA loads, indicative of acute infections, were in 10% hospitalised febrile infants, with 50% HIV-1+. Whereas high sera loads were in 1% of asymptomatic infants, with 2% HIV-1+, and higher levels in both HIV-1 infected or exposed, but negative infants. All 8 linked-hypervariable glycoprotein gN-gO genotypes were shown, including identification of a new gN4d group with gO5 linkage (previously only Merlin reference strain), and samples with multiple infections. Overall, this shows global genotypes in Africa (unlike some herpesviruses) and acute pediatric HCMV infections in both HIV-1+ plus exposed, but uninfected infants, an emerging group. (C) 2008 Elsevier Inc. All rights reserved.

Additional Information:The final published version of this article can be accessed online at https://www.sciencedirect.com/science/article/pii/S0042682208005801?via%3Dihub
Keywords:Human cytomegaloviru, Virus genotypes, African pediatric HIV/AIDS, Real time quantitative PCR, HIV-1 exposure, Viral loads, Virus phylogeny, Glycoprotein gN, Glycoprotein gO}
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Science > School of Life Sciences
ID Code:28411
Deposited On:23 Aug 2018 11:00

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