Micronutrient fortification to improve growth and health of maternally HIV-unexposed and exposed Zambian infants: a randomised controlled trial

Filteau, Suzanne and Kasonka, Lackson and Gibson, Rosalind and Gompels, Ursula A. and Jaffar, Shabbar and Kafwembe, Emmanuel and Monze, Mwaka and Sinkala, Moses and Tomkins, Andrew and Zulu, Rodah and Chisenga, Molly and Siame, Joshua and Mabuda, Hildah Banda and Baisley, Kathy and Dale, Helen and Rehman, Andrea and Bates, Matthew and Mullen, Anne and Bwalya, Hellen Kangwa and Chileshe, Margaret and Kowa, Priscilla Kangwa and Kumwenda, Mabvuto and Likando, Munalula and Mambwe, Sydney and Muzyamba, Mutinta and Mwale, Anne and Nyaywa, Lungowe and Kapambwe, Mirriam and Bima, Humphrey and Gosset, Laura and Hackett, Louise and Jackson, Abigail and Njunju, Eric and Mwanza, Sydney and Shampwaya, Natalia and Kabanga, Concillia and Chobo, John and Kapumba, Winford and Musonda, Charity and Soko, Philip (2010) Micronutrient fortification to improve growth and health of maternally HIV-unexposed and exposed Zambian infants: a randomised controlled trial. PLoS One, 5 (6). ISSN 1932-6203

Full content URL: https://doi.org/10.1371/journal.pone.0011165

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Abstract

Background: The period of complementary feeding, starting around 6 months of age, is a time of high risk for growth faltering and morbidity. Low micronutrient density of locally available foods is a common problem in low income countries. Children of HIV-infected women are especially vulnerable. Although antiretroviral prophylaxis can reduce breast milk HIV transmission in early infancy, there are no clear feeding guidelines for after 6 months. There is a need for acceptable, feasible, affordable, sustainable and safe (AFASS by WHO terminology) foods for both HIV-exposed and unexposed children after 6 months of age. Methods and Findings: We conducted in Lusaka, Zambia, a randomised double-blind trial of two locally made infant foods: porridges made of flour composed of maize, beans, bambaranuts and groundnuts. One flour contained a basal and the other a rich level of micronutrient fortification. Infants (n = 743) aged 6 months were randomised to receive either regime for 12 months. The primary outcome was stunting (length-for-age Z < -2) at age 18 months. No significant differences were seen between trial arms overall in proportion stunted at 18 months (adjusted odds ratio 0.87; 95% CI 0.50, 1.53; P = 0.63), mean length-for-age Z score, or rate of hospital referral or death. Among children of HIV-infected mothers who breastfed <6 months (53% of HIV-infected mothers), the richly-fortified porridge increased length-for-age and reduced stunting (adjusted odds ratio 0.17; 95% CI 0.04, 0.84; P = 0.03). Rich fortification improved iron status at 18 months as measured by hemoglobin, ferritin and serum transferrin receptors. Conclusions: In the whole study population, the rich micronutrient fortification did not reduce stunting or hospital referral but did improve iron status and reduce anemia. Importantly, in the infants of HIV-infected mothers who stopped breastfeeding before 6 months, the rich fortification improved linear growth. Provision of such fortified foods may benefit health of these high risk infants.

Keywords:micronutrient, feed supplement, HIV-exposed, zambia, Zambian, children
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Science > School of Life Sciences
ID Code:28408
Deposited On:17 Oct 2017 12:09

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