Neural model of dopaminergic control of arm movements in Parkinson’s disease bradykinesia

Cutsuridis, Vassilis (2006) Neural model of dopaminergic control of arm movements in Parkinson’s disease bradykinesia. In: Artificial Neural Networks – ICANN 2006, 10 - 14 September 2006, Athens, Greece.

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Item Type:Conference or Workshop contribution (Paper)
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Abstract

Patients suffering from Parkinson’s disease display a number of
symptoms such a resting tremor, bradykinesia, etc. Bradykinesia is the hallmark
and most disabling symptom of Parkinson’s disease (PD). Herein, a basal
ganglia-cortico-spinal circuit for the control of voluntary arm movements in PD
bradykinesia is extended by incorporating DAergic innervation of cells in the
cortical and spinal components of the circuit. The resultant model simulates
successfully several of the main reported effects of DA depletion on neuronal,
electromyographic and movement parameters of PD bradykinesia.

Keywords:neural model
Subjects:B Subjects allied to Medicine > B140 Neuroscience
G Mathematical and Computer Sciences > G730 Neural Computing
Divisions:College of Science > School of Computer Science
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ID Code:27747
Deposited On:30 Jun 2017 14:15

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