A simulation study on the effects of dendritic morphology on layer V prefrontal pyramidal cell firing behaviour

Psarou, Maria and Stefanou, Stefanos and Papoutsi, Athanasia and Tzilivaki, Alexandra and Cutsuridis, Vassilis and Poirazi, Panayiota (2014) A simulation study on the effects of dendritic morphology on layer V prefrontal pyramidal cell firing behaviour. Frontiers in Cellular Neuroscience . ISSN 1662-5102

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Abstract

Pyramidal cells, the most abundant neurons in neocortex, exhibit significant structural variability across different brain areas and layers in different species. Moreover, in response to a somatic step current, these cells display a range of firing behaviors, the most common being (1) repetitive action potentials (Regular Spiking—RS), and (2) an initial cluster of 2–5 action potentials with short interspike interval (ISIs) followed by single spikes (Intrinsic Bursting—IB). A correlation between firing behavior and dendritic morphology has recently been reported. In this work we use computational modeling to investigate quantitatively the effects of the basal dendritic tree morphology on the firing behavior of 112 three-dimensional reconstructions of layer V PFC rat pyramidal cells. Particularly, we focus on how different morphological (diameter, total length, volume, and branch number) and passive [Mean Electrotonic Path length (MEP)] features of basal dendritic trees shape somatic firing when the spatial distribution of ionic mechanisms in the basal dendritic trees is uniform or non-uniform. Our results suggest that total length, volume and branch number are the best morphological parameters to discriminate the cells as RS or IB, regardless of the distribution of ionic mechanisms in basal trees. The discriminatory power of total length, volume, and branch number remains high in the presence of different apical dendrites. These results suggest that morphological variations in the basal dendritic trees of layer V pyramidal neurons in the PFC influence their firing patterns in a predictive manner and may in turn influence the information processing capabilities of these neurons.

Keywords:dendrites, PFC, morphology, pyramidal cell, single neuron modeling, firing pattern, layer V, NotOAChecked
Subjects:B Subjects allied to Medicine > B140 Neuroscience
G Mathematical and Computer Sciences > G730 Neural Computing
Divisions:College of Science > School of Computer Science
ID Code:27735
Deposited On:03 Jul 2017 09:53

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