Deciphering the CA1 inhibitory circuits in sharp wave ripple complexes

Cutsuridis, Vassilis and Taxidis, Jiannis (2013) Deciphering the CA1 inhibitory circuits in sharp wave ripple complexes. Frontiers in Systems Neuroscience . ISSN 1662-5137

Full content URL: https://doi.org/10.3389/fnsys.2013.00013

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Abstract

Sharp wave-ripples (SWRs) are population oscillatory patterns in hippocampal LFPs during deep sleep and immobility, involved in the replay of memories acquired during wakefulness. SWRs have been extensively studied, but their exact generation mechanism is still unknown. A computational model has suggested that fast perisomatic inhibition may generate the high frequency ripples (~200 Hz). Another model showed how replay of memories can be controlled by various classes of inhibitory interneurons targeting specific parts of pyramidal cells (PC) and firing at particular SWR phases. Optogenetic studies revealed new roles for interneuronal classes and rich dynamic interplays between them, shedding new light in their potential role in SWRs. Here, we integrate these findings in a conceptual model of how dendritic and somatic inhibition may collectively contribute to the SWR generation. We suggest that sharp wave excitation and basket cell (BC) recurrent inhibition synchronises BC spiking in ripple frequencies. This rhythm is imposed on bistratified cells which prevent pyramidal bursting. Axo-axonic and stratum lacunosum/moleculare interneurons are silenced by inhibitory inputs originating in the medial septum. PCs receiving rippling inhibition in both dendritic and perisomatic areas and excitation in their apical dendrites, exhibit sparse ripple phase-locked spiking.

Keywords:sharp wave-ripple complexes, inhibition, hippocampus, memory consolidation, medial septum
Subjects:B Subjects allied to Medicine > B140 Neuroscience
G Mathematical and Computer Sciences > G730 Neural Computing
Divisions:College of Science > School of Computer Science
ID Code:27728
Deposited On:04 Jul 2017 11:41

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