Stability of parenteral nanoemulsions loaded with paclitaxel: the influence of lipid phase composition, drug concentration and storage temperature

Kadam, A. N. and Najlah, M. and Wan, K.-W. and Ahmed, W. and Crean, S. J. and Phoenix, D. A. and Taylor, K. M. G. and Elhissi, A. M. A. (2014) Stability of parenteral nanoemulsions loaded with paclitaxel: the influence of lipid phase composition, drug concentration and storage temperature. Pharmaceutical Development and Technology, 19 (8). pp. 999-1004. ISSN 1083-7450

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Paclitaxel was loaded into licensed parenteral nutrition nanoemulsions (Clinoleic® and Intralipid®) using bath sonication, and the stability of the formulations was investigated following storage for two weeks at room temperature or at 4°C. In general, Clinoleic droplets were smaller than Intralipid droplets, being around 255 and 285nm, respectively, for blank and freshly loaded emulsions. Regardless of storage temperature, the Clinoleic exhibited a very slight or no increase in droplet size upon storage, whilst the droplet size of the Intralipid emulsion increased significantly. The droplet size of both emulsions was minimally affected by paclitaxel concentration within the range of 0, 1, 3 and 6mg/ml. The pH of both emulsions markedly decreased upon storage at room temperature, which was possibly attributed to the production of fatty acids resulting from phospholipid hydrolysis. However, at 4°C, the pH of Clinoleic emulsion was unaffected by storage or paclitaxel concentration while the Intralipid emulsion demonstrated a trend for pH reduction. Both nanoemulsions had a negative zeta potential, with the Clinoleic formulations having the highest charge, possibly explaining the better size stability of this emulsion. Overall, this study has shown that paclitaxel was successfully loaded into clinically licensed parenteral emulsions and that Clinoleic showed greater stability than the Intralipid. © 2014 Informa Healthcare USA, Inc.

Keywords:clinoleic, essential fatty acid, fatty acid, glycerol, lipid, oleate sodium, paclitaxel, phospholipid, article, hydrolysis, nanoemulsion, nanotechnology, parenteral nutrition, pH, priority journal, room temperature, storage temperature, ultrasound, zeta potential, Antineoplastic Agents, Phytogenic, Drug Stability, Drug Storage, Emulsions, Fat Emulsions, Intravenous, Phospholipids, Plant Oils, Soybean Oil, Temperature, NotOAChecked
Subjects:F Physical Sciences > F200 Materials Science
J Technologies > J510 Materials Technology
Divisions:College of Science > School of Mathematics and Physics
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ID Code:27123
Deposited On:06 Jul 2017 11:37

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