The ‘affect tagging and consolidation’ (ATaC) model of depression vulnerability

Harrington, Marcus and Pennington, Kyla and Durrant, Simon (2017) The ‘affect tagging and consolidation’ (ATaC) model of depression vulnerability. Neurobiology of Learning and Memory . ISSN 1074-7427

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Abstract

Since the 1960’s polysomnographic sleep research has demonstrated that depressive episodes are associated with REM sleep alterations. Some of these alterations, such as increased REM sleep density, have also been observed in first-degree relatives of patients and remitted patients, suggesting that they may be vulnerability markers of major depressive disorder (MDD), rather than mere epiphenomena of the disorder. Neuroimaging studies have revealed that depression is also associated with heightened amygdala reactivity to negative emotional stimuli, which may also be a vulnerability marker for MDD. Several models have been developed to explain the respective roles of REM sleep alterations and negatively-biased amygdala activity in the pathology of MDD, however the possible interaction between these two potential risk-factors remains uncharted. This paper reviews the roles of the amygdala and REM sleep in the encoding and consolidation of negative emotional memories, respectively. We present our ‘affect tagging and consolidation’ (ATaC) model, which argues that increased REM sleep density and negatively-biased amygdala activity are two separate, genetically influenced risk-factors for depression which interact to promote the development of negative memory bias – a well-known cognitive vulnerability marker for depression. Predictions of the ATaC model may motivate research aimed at improving our understanding of sleep dependent memory consolidation in depression aetiology.

Keywords:rapid eye movement (REM) sleep, amygdala, emotional memory bias, emotional memory consolidation, depression
Subjects:C Biological Sciences > C850 Cognitive Psychology
B Subjects allied to Medicine > B140 Neuroscience
Divisions:College of Social Science > School of Psychology
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ID Code:26503
Deposited On:01 Mar 2017 09:22

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