Amphipol-encapsulated CuInS2/ZnS quantum dots with excellent colloidal stability

Booth, Matthew and Peel, Rebecca and Partanen, Riitta and Hondow, Nicole and Vasilca, Vlad and Jeuken, Lars J. C. and Critchley, Kevin (2013) Amphipol-encapsulated CuInS2/ZnS quantum dots with excellent colloidal stability. RSC Advances, 3 (43). p. 20559. ISSN 2046-2069

Full content URL: http://dx.doi.org/10.1039/C3RA43846E

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Abstract

CuInS2 quantum dots encapsulated in ZnS shells have emerged as less-toxic alternatives to cadmium-based nanoparticles. A well-established synthesis route for hydrophobic CIS/ZnS core/shell QDs has been developed using dodecanethiol as a ligand, solvent and source of sulfur, although the transfer of these nanoparticles into the aqueous phase still proves to be non-trivial. In this study we demonstrate that coating CIS/ZnS with an amphipol, poly(maleic anhydride-alt-1-tetradecene), 3-(dimethylamino)-1-propylamine derivative is an effective method to disperse CIS/ZnS QDs in the aqueous environment. The polymer-coated QDs display good colloidal stability over a wide pH range and low sensitivity to the presence of various metal salts, except Cu2+ for which some sensitivity is observed. Cytotoxic effects were tested in HaCat cells and compared to thioglycolic acid modified CdTe/ZnS QDs. Neither CdTe nor CIS QDs decreased viability until above 10 μg mL−1 in a WST-1 assay. By also assessing the toxicity of the PMAL-d polymer it is clear that remaining toxicity of the CIS/ZnS QDs is predominately due to the polymer coating rather than the QD core. Interestingly, MTT assays seem to artificially exaggerate cytotoxicity of the QDs, which we ascribe to the QDs interfering with the MTT or formazan crystals.

Keywords:Qauntum Dots, Copper Indium Disulfide, Amphipol
Subjects:F Physical Sciences > F200 Materials Science
F Physical Sciences > F162 Polymer Chemistry
Divisions:College of Science > School of Mathematics and Physics
ID Code:25263
Deposited On:26 Nov 2016 19:47

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