Increased reflection impulsivity in patients with ephedrone-induced Parkinsonism

Djamshidian, Atbin and Sanotsky, Yanosh and Matviyenko, Yuriy and O'Sullivan, Sean S. and Sharman, Stephen and Selikhova, Marianna and Fedoryshyn, Ludmyla and Filts, Yuriy and Bearn, Jenny and Lees, Andrew J. and Averbeck, Bruno B. (2013) Increased reflection impulsivity in patients with ephedrone-induced Parkinsonism. Addiction, 108 (4). pp. 771-779. ISSN 0965-2140

Full content URL: http://dx.doi.org/10.1111/add.12080

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Abstract

Abstract

Aims

To examine a syndrome of chronic manganism that occurs in drug addicts in eastern Europe who use intravenous methcathinone (ephedrone) contaminated with potassium permanganate. In many cases the basal ganglia, especially the globus pallidus and the putamen, are damaged irreversibly. Routine neuropsychological assessment has revealed no cognitive deficits, despite widespread abnormalities on brain imaging studies and severe extrapyramidal motor handicap on clinical examination.
Design

Case–control study.
Setting

Ephedrone patients and patients with opioid dependence were recruited from Lviv, Ukraine.
Participants

We tested 15 patients with ephedrone-induced toxicity, 13 opiate-dependent patients who were receiving opioid replacement therapy and 18 matched healthy volunteers.
Measurements

The ‘beads task’, an information-gathering task to assess reflection impulsivity, was used and feedback learning, working memory and risk-taking were also assessed.
Findings

Opiate-dependent patients differed from controls on three of four tasks, whereas ephedrone patients differed from controls on only one task. More specifically, both patient groups were more impulsive and made more irrational choices on the beads task than controls (P < 0.001). However, ephedrone patients had no deficits in working memory (P > 0.1) or risk-taking (P > 0.1) compared with controls. Opioid-dependent patients had significantly worse working memory (P < 0.001) and were significantly more risk-prone than controls (P = 0.002).
Conclusions

Ephedrone patients may have similar deficits in information-gathering and decision-making to opiate-dependent patients, with preservation of working memory and risk-taking. This may reflect specific damage to anterior cingulate– basal ganglia loops.

Keywords:Parkinson's disease, decision-making, gambling, Impulsivity, reflection impulsivity
Subjects:C Biological Sciences > C800 Psychology
C Biological Sciences > C830 Experimental Psychology
C Biological Sciences > C841 Health Psychology
Divisions:College of Social Science > School of Psychology
ID Code:24980
Deposited On:18 Nov 2016 09:53

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