Quantification and characterisation of fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease

Walker, M. P. and Ayre, G. A. and Perry, E. K. and Wesnes, K. and McKeith, I. G. and Tovee, Martin and Edwardson, J. A. and Ballard, C. G. (2000) Quantification and characterisation of fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 11 (6). pp. 327-335. ISSN 1420-8008

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Item Type:Article
Item Status:Live Archive

Abstract

Fluctuating cognition (FC) is a common and important symptom in dementia, particularly dementia with Lewy bodies (DLB), although it has not been empirically quantified or characterised. Forty subjects (15 DLB, 15 AD, 10 elderly controls) were evaluated using a clinical FC severity scale, as well as receiving measures of variability in attentional performance and slow EEG rhythms across 90 s, 1 h and 1 week. DLB patients had significantly more severe FC and more severe variability in attentional and slow electrocortical measures than either AD patients or normal controls in all time frames. Attentional and EEG variability also correlated significantly with independent clinical ratings of FC. Clinical quantification and measures of attention and EEG variability can therefore make an important and standardised contribution to the assessment of FC in dementia, facilitating future treatment studies with important implications for the potential causative mechanisms and differential diagnosis.

Keywords:Fluctuating cognition, Variability, Attention, Delta power, Dementia with Lewy bodies, Alzheimer’s disease
Subjects:C Biological Sciences > C800 Psychology
C Biological Sciences > C850 Cognitive Psychology
C Biological Sciences > C841 Health Psychology
C Biological Sciences > C810 Applied Psychology
C Biological Sciences > C840 Clinical Psychology
Divisions:College of Social Science > School of Psychology
ID Code:24499
Deposited On:16 Aug 2017 15:07

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