Fluctuations in attention: PD dementia vs DLB with parkinsonism

Ballard, C.G. and Aarsland, D. and McKeith, I. and O'Brien, J. and Gray, A. and Cormaak, F. and Burn, D. and Cassidy, T. and Starfeldt, R. and Larsen, J.-P. and Brown, R. and Tovee, Martin (2002) Fluctuations in attention: PD dementia vs DLB with parkinsonism. Neurology, 59 (11). pp. 1714-1720. ISSN 0028-3878

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Item Type:Article
Item Status:Live Archive

Abstract

Background: Marked impairments in and fluctuation of attention are characteristic of dementia with Lewy bodies (DLB). The comparative impairment of these cognitive domains in PD and PD dementia (PD dementia) has not been studied, and is important to the conceptual understanding of parkinsonian dementias. Method: Detailed evaluations of attention and fluctuating attention (Cognitive Drug Research computerized battery) were undertaken in 278 subjects (50 DLB, 48 PD dementia, 50 PD, 80 AD, 50 elderly controls) from the Newcastle dementia register and the Stavanger PD register (controls, PD, and PD dementia patients were recruited from both centers). DLB, AD, PD, and PD dementia were diagnosed using operationalized criteria. Results: Impairments in reaction time, vigilance, and fluctuating attention were comparable in patients with DLB and PD dementia, but were less substantially impaired in patients with DLB without parkinsonism. Patients with PD had significantly greater impairment of cognitive reaction time than elderly controls, and comparable impairments of cognitive reaction time to patients with AD. Patients with PD, however, did not exhibit fluctuation of attention. Conclusion: The profile of attentional impairments and fluctuating attention is similar in PD dementia and DLB with parkinsonism. The current findings do not support the current arbitrary distinctions between these patient groups. Importantly, patients with PD do not experience fluctuating attention.

Keywords:attention, cognition, Lewy body, Parkinson disease, parkinsonism, Dementia, Electroencephalography, Lewy Body Disease, Neuropsychological Tests, Reaction Time
Subjects:C Biological Sciences > C800 Psychology
C Biological Sciences > C850 Cognitive Psychology
C Biological Sciences > C830 Experimental Psychology
C Biological Sciences > C841 Health Psychology
C Biological Sciences > C840 Clinical Psychology
Divisions:College of Social Science > School of Psychology
ID Code:24484
Deposited On:11 Aug 2017 11:12

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