Use of positron emission tomography (PET) in stereotactic conditions for brain biopsy

Pirotte, B. and Goldman, S. and Bidaut, L. M. and Luxen, A. and Stanus, E. and Brucher, J.-M. and Baleriaux, D. and Brotchi, J. and Levivier, M. (1995) Use of positron emission tomography (PET) in stereotactic conditions for brain biopsy. Acta Neurochirurgica, 134 (1-2). pp. 79-82. ISSN 0001-6268

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Item Type:Article
Item Status:Live Archive

Abstract

In order to take advantage of the metabolic information provided by positron emission tomography (PET) in cases of brain tumour, we have developed a technique to integrate PET images routinely in the planning of stereotactic brain biopsy. We used stereotactic PET with 18F-labelled fluorodeoxyglucose (PET-FDG) in 38 patients undergoing brain biopsy. To evaluate the contribution of PET-FDG in guiding brain biopsy, we analyzed the diagnosis provided by the 78 Stereotactic trajectories obtained in these patients. We found that stereotactic PET-FDG seemed to provide more information in cases of anaplastic astrocytomas and glioblastomas than in low-grade gliomas. Our results also show that biopsy trajectories performed in areas where increased FDG uptake is found within the lesion boundaries always provide interpretable specimens; this was not the case for trajectories guided by CT only. Therefore, the routine integration PET-FDG in the planning of stereotactic brain biopsy may lead to a reduction in sampling. Recently, we also tested consecutive stereotactic PET with 11C-labelled methionine (PET-Met) and PET-FDG. This technique allowed us to compare accurately the tumoural glucose metabolism and protein synthesis. Our results suggest that stereotactic PET may increase the diagnostic yield of brain biopsy and may improve the understanding of PET in neuro-oncology. © 1995 Springer-Verlag.

Keywords:carbon 11, fluorodeoxyglucose f 18, glucose, methionine, protein, adult, aged, brain biopsy, brain metabolism, brain tomography, brain tumor, clinical article, clinical trial, computer assisted tomography, conference paper, controlled clinical trial, controlled study, female, glioblastoma, glioma, glucose metabolism, human, intermethod comparison, male, positron emission tomography, preoperative evaluation, priority journal, protein synthesis, stereotaxic surgery, Adult, Astrocytoma, Biopsy, Blood Glucose, Brain, Brain Neoplasms, Deoxyglucose, Energy Metabolism, Fluorodeoxyglucose F18, Humans, Middle Aged, Neoplasm Proteins, Stereotaxic Techniques, Tomography, Emission-Computed
Subjects:F Physical Sciences > F350 Medical Physics
Divisions:College of Science > School of Computer Science
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ID Code:24173
Deposited On:26 Oct 2016 11:06

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