Breast cancer metastasis: challenges and opportunities

Lu, Jing and Steeg, Patricia S. and Price, Janet E. and Krishnamurthy, Savitri and Mani, Sendurai A. and Reuben, James and Cristofanilli, Massimo and Dontu, Gabriela and Bidaut, Luc and Valero, Vincente and Hortobagyi, Gabriel N. and Yu, Dihua (2009) Breast cancer metastasis: challenges and opportunities. Cancer Research, 69 (12). pp. 4951-4953. ISSN 0008-5472

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Abstract

Despite exciting progress in the understanding of breast cancer
development and progression, and in the development of novel
therapeutic strategies, breast cancer remains the second leading
cause of cancer-related death in women, with a yearly toll of more
than 40,000 deaths in the United States alone. Breast cancer–related
deaths are mainly due to the “incurable” nature of metastatic
breast cancer (MBC) at the current time. It is estimated that
∼6% of patients have metastatic disease at the time of diagnosis
and 20% to 50% patients first diagnosed with primary breast cancer
will eventually develop metastatic disease. Even with the remarkable
advances in research and clinical management, the
current treatment strategies for breast cancer metastasis still
largely rely on the use of systemic cytotoxic agents, which frequently
deteriorate the patient's life quality due to severe side
effects and, in many cases, have limited long-term success. The
prognosis for MBC patients is poor, with an estimated 5-year survival
of only 26%. Therefore, MBC remains the most challenging
task facing both cancer researcher and oncologist. To tackle this
challenge, scientists and physicians of the Breast Cancer Research
Program at the M.D. Anderson Cancer Center held a symposium to
(a) provide a better understanding of breast cancer metastasis at
the molecular and cellular level; (b) introduce cutting-edge technologies
in metastatic breast cancer detection, including clinicopathologic
detection, circulating tumor cells (CTC) detection, and
advanced imaging; and (c) solicit innovative ideas in basic, translational
research and clinical patient management. The symposium
led to a positive consensus notion that we will be able to prevent,
and to a lesser degree, treat metastasis and ultimately save most
patients from metastatic deaths in the foreseeable future.

Keywords:aldehyde dehydrogenase, aromatase inhibitor, capecitabine, docetaxel, doxorubicin, gemcitabine, lapatinib, paclitaxel, trastuzumab, blood brain barrier, bone metastasis, brain metastasis, brain radiation, breast cancer, cancer chemotherapy, cancer mortality, cancer stem cell, cancer survival, carcinogenesis, computer assisted tomography, conference paper, drug penetration, histopathology, human, liver metastasis, lung metastasis, lymph node metastasis, neurosurgery, nonhuman, nuclear magnetic resonance imaging, positron emission tomography, priority journal, prognosis, single photon emission computer tomography, stereotactic radiosurgery, tumor cell, ultrasound, Animals, Breast Neoplasms, Disease Models, Animal, Humans, Neoplasm Metastasis
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
Divisions:College of Science > School of Computer Science
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ID Code:24141
Deposited On:07 Apr 2017 11:08

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