Relationships among body mass index, longitudinal body composition alterations, and survival in patients with locally advanced pancreatic cancer receiving chemoradiation: a pilot study

Dalal, Shalini and Hui, David and Bidaut, Luc and Lem, Kristen and Del Fabbro, Egidio and Crane, Christopher and Reyes-Gibby, Cielito C. and Bedi, Deepak and Bruera, Eduardo (2012) Relationships among body mass index, longitudinal body composition alterations, and survival in patients with locally advanced pancreatic cancer receiving chemoradiation: a pilot study. Journal of Pain and Symptom Management, 44 (2). pp. 181-191. ISSN 0885-3924

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Item Type:Article
Item Status:Live Archive

Abstract

Context: In pancreatic cancer, the presence of obesity or weight loss is associated with higher mortality. Objectives: To explore the relationships among body mass index, longitudinal body composition alterations, and clinical outcomes in pancreatic cancer patients. Methods: Records of 41 patients with inoperable locally advanced pancreatic cancer who participated in a prospective chemoradiation study were reviewed. Body composition was analyzed from two sets of computed tomography images obtained before and after radiation treatment (median interval 104 days). Results: Median age was 59 years and 56 of patients were female. Twenty-four (59) patients were either overweight (22) or obese (37). Sarcopenia was present in 26 (63) patients. At follow-up, weight loss was experienced by 33 (81) patients. The median losses () before and after treatment were weight 5 (P < 0.001), skeletal muscle (SKM) 4 (P = 0.003), visceral adipose tissue (VAT) 13 (P < 0.001), and subcutaneous adipose tissue 11 (P = 0.002). SKM loss positively correlated with age (P = 0.03), baseline body mass index (P < 0.001), and VAT (P = 0.04) index. Obese patients experienced higher losses in weight (P = 0.009), SKM (P = 0.02), and VAT (P = 0.02). Median survival was 12 months. In univariate analysis, age, baseline obesity, sarcopenic obesity, and losses () in weight, SKM, and VAT were associated with worse survival. In multivariate analysis, only age (hazard ratio = 1.033, P = 0.04) and higher VAT loss (hazard ratio = 2.6 and P = 0.03) remained significant. Conclusion: Our preliminary findings suggest that obese patients experience higher losses in weight, SKM, and VAT, which may contribute to poorer survival in these patients. © 2012 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

Keywords:bevacizumab, capecitabine, adult, advanced cancer, age, aged, article, body composition, body mass, cancer patient, cancer survival, chemoradiotherapy, clinical article, computer assisted tomography, female, follow up, human, inoperable cancer, intraabdominal fat, male, mortality, muscle atrophy, obesity, pancreas cancer, pilot study, skeletal muscle, subcutaneous fat, survival time, treatment outcome, weight reduction, Adipose Tissue, Adult, Aged, 80 and over, Anthropometry, Body Mass Index, Cachexia, Humans, Kaplan-Meier Estimate, Longitudinal Studies, Middle Aged, Muscle, Skeletal, Pancreatic Neoplasms, Pilot Projects, Prognosis, Prospective Studies, Survival Analysis, Weight Loss
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
Divisions:College of Science > School of Computer Science
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ID Code:24123
Deposited On:25 Oct 2016 12:49

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