Impaired blood neutrophil function in the frequent exacerbator of chronic obstructive pulmonary disease: a proof of concept study

Jones, Arwel W. and Robinson, Richard and Mohamed, Peer and Davison, Glen and Izzat, Hassan J. and Lewis, Keir E. (2016) Impaired blood neutrophil function in the frequent exacerbator of chronic obstructive pulmonary disease: a proof of concept study. Lung, 194 (6). pp. 881-887. ISSN 0341-2040

Full content URL: http://dx.doi.org/10.1007/s00408-016-9930-z

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Abstract

Purpose
The underlying biological mechanisms of the frequent exacerbator phenotype of COPD remain unclear. We compared systemic neutrophil function in COPD patients with or without frequent exacerbations.
Methods
Whole blood from COPD frequent exacerbators (defined as ≥ 2 moderate-severe exacerbations in the previous 2 years), and non-exacerbators (no exacerbations in the preceding 2 years) was assayed for neutrophil function. Neutrophil function in healthy ex-smoking volunteers was also measured as a control (reference) group.
Results
A total of 52 subjects were included in this study; 26 frequent exacerbators, 18 non-exacerbators and 8 healthy controls. COPD frequent exacerbators had blunted blood neutrophil fMLP-stimulated oxidative burst compared to both non-exacerbators (p < 0.01) and healthy controls (p < 0.001). There were no differences between COPD frequent exacerbators and non-exacerbators in blood neutrophil PMA-stimulated oxidative burst but both COPD groups had reduced responses compared to healthy controls (p < 0.001). Bacterial-stimulated neutrophil degranulation was greater in frequent exacerbators than non-exacerbators (p < 0.05).
Conclusion
This study is the first to report aberrant receptor-mediated blood neutrophil function in the frequent exacerbator of COPD.

Keywords:Chronic Obstructive Pulmonary Disease, granulocyte, elastase, reactive oxygen species, bmjdoi, JCOpen
Subjects:C Biological Sciences > C550 Immunology
A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Social Science > Lincoln Institute of Health
ID Code:23721
Deposited On:11 Aug 2016 11:55

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