Stabilisation of metastable polymorphs: the case of paracetamol form III

Telford, Richard and Seaton, Colin C. and Clout, Alexander and Buanz, Asma and Gaisford, Simon and Williams, Gareth R. and Prior, Timothy J. and Okoye, Chidera H. and Munshi, Tasnim and Scowen, Ian J. (2016) Stabilisation of metastable polymorphs: the case of paracetamol form III. Chem. Commun., 52 (81). pp. 12028-12031. ISSN 1359-7345

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The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.

Additional Information:This article is part of themed collection: Pharmaceutical Solids
Keywords:Pharmaceutical solids, JCOpen
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
ID Code:23720
Deposited On:11 Aug 2016 09:23

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