Polygenic risk of ischemic stroke is associated with cognitive ability

Harris, Sarah E. and Malik, Rainer and Marioni, Riccardo and Campbell, Archie and Seshadri, Sudha and Worrall, Bradford B. and Sudlow, Cathie L. M. and Hayward, Caroline and Bastin, Mark E. and Starr, John M. and Porteous, David J. and Wardlaw, Joanna M. and Deary, Ian J. and METASTROKE Consortium, . (2016) Polygenic risk of ischemic stroke is associated with cognitive ability. Neurology, 86 (7). pp. 611-618. ISSN 0028-3878

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Item Type:Article
Item Status:Live Archive

Abstract

OBJECTIVES

We investigated the correlation between polygenic risk of ischemic stroke (and its subtypes) and cognitive ability in 3 relatively healthy Scottish cohorts: the Lothian Birth Cohort 1936 (LBC1936), the Lothian Birth Cohort 1921 (LBC1921), and Generation Scotland: Scottish Family Health Study (GS).

METHODS

Polygenic risk scores for ischemic stroke were created in LBC1936 (n = 1005), LBC1921 (n = 517), and GS (n = 6,815) using genome-wide association study summary data from the METASTROKE collaboration. We investigated whether the polygenic risk scores correlate with cognitive ability in the 3 cohorts.

RESULTS

In the largest cohort, GS, polygenic risk of all ischemic stroke, small vessel disease stroke, and large vessel disease stroke, but not cardioembolic stroke, were correlated with both fluid and crystallized cognitive abilities. The highest correlation was between a polygenic risk score for all ischemic stroke and general cognitive ability (r = -0.070, p = 1.95 × 10(-8)). Few correlations were identified in LBC1936 and LBC1921, but a meta-analysis of all 3 cohorts supported the correlation between polygenic risk of ischemic stroke and cognitive ability.

CONCLUSIONS

The findings from this study indicate that even in the absence of stroke, being at high polygenic risk of ischemic stroke is associated with lower cognitive ability.

Keywords:Stroke, bmjidentity, NotOAChecked
Subjects:C Biological Sciences > C400 Genetics
Divisions:College of Science > School of Life Sciences
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ID Code:23606
Deposited On:01 Aug 2016 20:52

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